Sunday, February 1, 2009

MMP-9 formation and TNF mRNA stabilization

I do not usually do this outside of the NORTH MEDICAL CENTER site, but since it was such dramatic information …….

From 2002 data and informatic assimilation, it appears that the stabilization of TNF mRNA and its continued stimulation of MMP-9 formation and its stabilization, is the main culprit in cancer’s lethality. Now from 7 year old data we can see that methylation
of arginine is the method by which the HuR is stabilized. This again gives more hope to the hopeless with cancer. This is rather ironic in that the chemistry of arginine is involved in TH1 and TH2 differentiation as well as ornithine.

Alcohol is a substance that has been shown in HuR to increase its attraction to the mRNA of TNF. Take home message quit drinking!

Hongwei Li/Sungmin Park/Britta Kilburn/2002J. Biol. Chem. 277 (47): 44623-44630

No comments: