Thursday, February 12, 2009

Cytokines as anticancer treatments? Look at IL10 today and jalapenos

I assume that we can agree upon the tragedy of environmental toxins upon the
health of the world. Our diets make a difference as to the impact and exposure of these toxins. Vegetables, fruits that do not have pesticides can diminish the potential to these toxins such as oil by-products as well as other chemicals. Elimination of toxins from the food chain of the substance consumed can help also.

Nevertheless sometimes once one has been diagnosed with the dreaded initials MS, (multiple sclerosis) , SLE (systemic Lupus Erythematosis) or C word (Cancer), it is contingent upon him or her to eliminate the potential for their acceleration by continued exposure to toxins. The diminution of exposure diminishes potential of subsequent growth and toxicity of the cancer, MS or SLE or progression of the MS and the enhancement of response to treatments.

Some of this toxicity of the tumor is demonstrated through the production of the tumor of cytokines. Cytokines are of the inflammatory type produced by tumor cells and in general represent the Neanderthal but necessary Cro-Magnon but critical response to a foreign substance in normal White Blood Cells (lymphocytes) as allergic as opposed to antibody response. This is the Th1 response and yields the protein /hormone acting cytokines Interleukin 1, Interleukin 6 and Tumor Necrosis Factor (TNF) in normal lymphocytes under normal biochemical feedback inhibition

As in any protein production messenger RNA is templated if you will, to act as a pattern for each individual protein through Transfer RNA and nucleotide base assembly. Yet the critical length of time that the protein is produced necessary for its action is determined by the length of time the messenger RNA exits (its ½ life ). The substance HuR enhances the 1/2 life of the mRNA by attaching itself to the mRNA at the Uridine rich area. This throws the complete system of biochemical feedback inhibition off and there is an exaggerated production of things that become toxic.

The most toxic of these hormones is TNF because it is supposed to shrink tumors (tumor necrosis) but it turns on the collagenase/gelatinase MMP-9. The MMP-9 exposes more tissue if you will to requiring more TNF by penetrating neighboring basement membranes and hence a vicious cycle is created

What does all this mean? The HuR for the TNF and MMP-9 appear therefore to be the most likely candidate for cancer SLE, and MS treatment.
Keep your eyes pealed for natural and unconventional treatments that
effect this axis. IL10 appears to be a cytokine that may help in this endeavor.
Atorvastatin ( a statin drug lowering cholesterol ) increases IL10 and acts naturally to diminsh the inflammatory wing of the CYTOKINE CASCADE. So do jalapenos by blocking the receptor to Substance P which intiates the Inflammatory Cascade!

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