Sunday, January 18, 2009

MMp-9, HuR, NO (Nitrous Oxide)

It appears that Nitrous Oxide may have a tumor fighting effect.

According to some old data that I pulled up in another article, the introduction of Nitrous Oxide had an anti-tumor effect. What this means is that arginine biochemistry as well as anything that increases local Nitrous Oxide would diminish the tumor by increasing the decay of MMP-9 messenger RNA which causes a loss of integrity at basal membranes and causes cancer to spread. In other words it could be that a class of cancer fighting drugs may be on the order of Viagra.

In the normal state of MMP -9 physiology in Mesangial Cells

Besides the proinflammatory cytokines, Mesangial Cells are able to respond to a variety of other biological mediators including eicosanoids, growth factors, reactive oxygen species, NO, and to extracellular nucleotides such as ATP and UTP

Previously, we have demonstrated an additional mode of posttranscriptional regulation of MMP-9, which involves the reduction of cytokine-induced MMP-9 via reduction of mRNA stability exerted by exogenous and endogenouly produced NO (6).

ref 6 eberhardt w et all j biol chem vol 277 pg. 33518

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