see http://tinyurl.com/d6osnu
First of all MMP-9 as an enzyme has a normal function of remodeling the extracellular matrix. Without them as animal fat digestors the lack of remodeling probably would kill us by 22, and
we would die of heart attacks blind with renal failure. Talk about the metabolic syndrome! I wonder how much longer could we live sans exposure to animal fat.
Yu and Stamenkovicin 1999 were the first that I could find that associated the lack of inhibition of one of the most virulent cancer metastasis producers (MMP-9) to something outside of the molecule itself. In fact they surmised that the activity of the metaloproteinase was directly related to the physical restriction of an external cell receptor on the cell surface . It was they who surmised that the part of the iceburg that was necessary extended from the cell for the 'activation' if you will of the collagenase (MMP-9). This iceberg is a receptor for hyaluronan and docks the activated MMP-9 to do its thing. It is called CD44
We have discussed the role of HuR clinging in essential internal mRNA prolongation of 1/2 life. With these two substances so well researched 10 years ago you would think that the major cancer researchers especially in _____ would have cures related to them by now saving more lives. Yet they receive billions in federal kickback stimulation funds to continue restricting care to the indigent, especially the Black male. I call that indirect US paid genocide for hire. The legal profession is responsible for this as well as the legalized environmental racism which exposes poorer communities to known environmental toxins.
This will serve as the offical site of Advanced Medical Informatics Education. Our site is down
and we need to pay them. I will not be able to get a comparison to our old data but thank God we still have access to the net at least up until now. You can do the analytics now after I go on my forced no-internet sabatical on the 17th . There may be someone to take over the site. Let us hope so. Just compare MMP-9 to things that stop it and things that do not. There probable is a root in India , Africa or Brazil that can put it in check. Let us look for it.
Showing posts with label HuR. Show all posts
Showing posts with label HuR. Show all posts
Thursday, February 26, 2009
Monday, February 9, 2009
Dancers at the "ball" of MS, or 4th step
The continued separation of medicine is for politico-economic purposes only.
Without division there are greater possibilities for exchange of information.
This is particularly true for the kidney and the cardiovascular system. Due to their similar embryonic origin, studies involving glomerulonephritis invariably involve explanations of carditis. Since cardiologists do not seek after new treatments in the
nephrology field and vice versa there may be discoveries of sorts that are not being shared between the fields. There certainly has not been an economic stimulus to combine
departments at any medical schools that I know of. This would result in diminished
research funding and invasion of territory. There classically has been a competition
between the two fields and for one to be a cardiologist-nephrologist. Only a medical INFORMATICS department could have sway at collaborative studies in newly discovered information relative to cytokines and inflammatory causes of disease.
I realize this as I read articles form 2003 relative to the kidney that have similar pathologies in Multiple Scleorsis.
Here are the Players IL18, NK cells, HuR, MMP-9 ,TNF, IL1 cleaving
By studying one you solve the problem for 2. Lets block receptors of cytokines, prevent pro-enzyme activation, check our diet, drink water and figure this thing out. If your son had MS you would!
Nevertheless check this out
http://www.nature.com/ki/journal/v64/n1/full/4493856a.html
There is gold in them thar hills ( of nephrology), which will help us understand all disease.
You will love Advanced Medical Informatics Education (AMIE) and me too before it is all over, for the cures that it will bring your children and grandchildren! It may not be too late for your mental disease of evil. It is inflammatory and requires an antiinflammant treatment
( Anti Th1 )
Remember the all your fairy tales that your dad to told you? The stories?
If not we still love you but you need to read and act on the 4th step in 12/12 and do 1John 1:9 and repent while you have time, so you can begin to love yourself! PS do 1-3 then 5-12 thereafter
Without division there are greater possibilities for exchange of information.
This is particularly true for the kidney and the cardiovascular system. Due to their similar embryonic origin, studies involving glomerulonephritis invariably involve explanations of carditis. Since cardiologists do not seek after new treatments in the
nephrology field and vice versa there may be discoveries of sorts that are not being shared between the fields. There certainly has not been an economic stimulus to combine
departments at any medical schools that I know of. This would result in diminished
research funding and invasion of territory. There classically has been a competition
between the two fields and for one to be a cardiologist-nephrologist. Only a medical INFORMATICS department could have sway at collaborative studies in newly discovered information relative to cytokines and inflammatory causes of disease.
I realize this as I read articles form 2003 relative to the kidney that have similar pathologies in Multiple Scleorsis.
Here are the Players IL18, NK cells, HuR, MMP-9 ,TNF, IL1 cleaving
By studying one you solve the problem for 2. Lets block receptors of cytokines, prevent pro-enzyme activation, check our diet, drink water and figure this thing out. If your son had MS you would!
Nevertheless check this out
http://www.nature.com/ki/journal/v64/n1/full/4493856a.html
There is gold in them thar hills ( of nephrology), which will help us understand all disease.
You will love Advanced Medical Informatics Education (AMIE) and me too before it is all over, for the cures that it will bring your children and grandchildren! It may not be too late for your mental disease of evil. It is inflammatory and requires an antiinflammant treatment
( Anti Th1 )
Remember the all your fairy tales that your dad to told you? The stories?
If not we still love you but you need to read and act on the 4th step in 12/12 and do 1John 1:9 and repent while you have time, so you can begin to love yourself! PS do 1-3 then 5-12 thereafter
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