Brain Activity: And in Houston!!!: Definite Strategic Collaboration

Tuesday, April 7, 2009

Definite Strategic Collaboration

BEIJING, April 6 /PRNewswire/ -- BioDuro announced today that they have entered into a strategic partnership with Roche to support discovery phase research efforts at Roche's global research sites. BioDuro will provide research services in the areas of discovery chemistry and biology, which can help to shorten (internal) drug discovery timelines. This agreement is an expansion of an existing relationship.
Roche has many years of experience in partnering with external companies to complement its internal drug discovery expertise with external services and innovation. After extensive evaluation of many companies, Roche selected BioDuro as a strategic partner for this effort.
"Presently, there is intense competition within the CRO industry for outsourcing and drug discovery services, and the expectation is that they will deliver problem solving skills and innovation in both chemistry and biology," commented Robert Goodnow, Ph.D., Roche's Global Head of Medicinal Chemistry Outsourcing. "We selected BioDuro due to their demonstrated excellent performance in synthetic chemistry and ability to deliver integrated medicinal chemistry services."
"BioDuro is pleased to build upon this existing collaboration and work closely with the experienced team at Roche to aid in the development of novel therapeutics. We care deeply about working on projects that will impact the quality of life worldwide and working with Roche ensures this outcome. Our partnership demonstrates the strength of our innovative, fully integrated R&D service platform, and is a true testament to the caliber of scientists that have joined our team," commented John Oyler, Chief Executive Officer and co-founder of BioDuro LLC.
About Roche
Headquartered in Basel, Switzerland, Roche is one of the world's leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As the world's bigges'/>"/>

SOURCE BioDuroCopyright©2009 PR Newswire.All rights reserved

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Fraternity fraternal to whom within the church? I guess themselves!

FROM MLK DRUM MAJOR INSTINCT

And then the final great tragedy of the distorted personality is the fact that when one fails to harness this instinct, (Glory to God) he ends up trying to push others down in order to push himself up. (Amen) And whenever you do that, you engage in some of the most vicious activities. You will spread evil, vicious, lying gossip on people, because you are trying to pull them down in order to push yourself up. (Make it plain) And the great issue of life is to harness the drum major instinct.
Now the other problem is, when you don't harness the drum major instinct—this uncontrolled aspect of it—is that it leads to snobbish exclusivism. It leads to snobbish exclusivism. (Make it plain) And you know, this is the danger of social clubs and fraternities—I'm in a fraternity; I'm in two or three—for sororities and all of these, I'm not talking against them. I'm saying it's the danger. The danger is that they can become forces of classism and exclusivism where somehow you get a degree of satisfaction because you are in something exclusive. And that's fulfilling something, you know—that I'm in this fraternity, and it's the best fraternity in the world, and everybody can't get in this fraternity. So it ends up, you know, a very exclusive kind of thing.And you know, that can happen with the church; I know churches get in that bind sometimes. (Amen, Make it plain) I've been to churches, you know, and they say, "We have so many doctors, and so many school teachers, and so many lawyers, and so many businessmen in our church." And that's fine, because doctors need to go to church, and lawyers, and businessmen, teachers—they ought to be in church. But they say that—even the preacher sometimes will go all through that—they say that as if the other people don't count. (Amen)

Lithium Pricing ..HMMMMM

As to availability, first I went to http://www.wikipedia.org/ and looked up the word Lithium. It states that "...It forms a minor part of almost all igneous rocks and is also found in many natural brines. Lithium is the thirty-first most abundant element... The Earth's crust contains 65 parts per million of lithium." Apparently there is plenty of lithium on this planet.
However, there is still something that we should be aware of, and maybe even be concerned about. That is, the lithium market is characterized by a high degree of consolidation. This is another way of saying that production and prices are subject to control by a very few large multinational corporations. Reminds me of DeBeers controlling the diamond market.
Three major producers represent a large part of the world's lithium mineral output. SQM and SCL (part of Chemetall) control the supply of lithium carbonate to a great extent, while Chemetall of Germany and FMC of the USA dominate the manufacture of lithium metal and chemicals. This information was gleamed from the U.S. Geological Survey Minerals Yearbook - 2004. (http://minerals.usgs.gov/minerals/pubs/commodity/lithium/), and Roskill Metals and Minerals Reports (http://www.roskill.com/reports/lithium/contents).
The USGS Yearbook states that "Production and stock data (of lithium) were withheld from publication to avoid disclosing company proprietary data". As a side note, the US Government stockpile of lithium is: None.
This Yearbook also states that "... It has become difficult to obtain reliable price information from companies or trade publications. Companies may announce price hikes, but they are reported relative only to previous prices. Producers negotiate with consumers on an individual basis; price information is not usually reported." (Why the secrecy???) and "Customs values for lithium carbonate imports to the United States are a good inidication of the trends in lithium pricing, although they have never exactly reflected the producers' prices for lithium carbonate. In 2004, the average customs unit value for imported lithium carbonate was $1.72 per kilogram, about 11% higher than in 2003." Lithium at $1.72 kg equals $3.79 lb.
Per the Metals Chart at www.infomine.com/, the two year (March 1, 2004 to March 1, 2006) price ranges are for: Lead US$.32 to $.66 lb, Silver (it is used in lead-acid batteries) $66.00 to $119.00 lb, Copper $1.24 to $2.27 lb, and Nickel $4.80 to $8.10 lb. For comparison purposes, find out how much of each metal is used in each battery, then you can get a rough idea of the raw material cost that goes into each battery.

http://www.evworld.com/blogs/index.cfm?page=blogentry&blogid=211&authorid=81&archive=0

Thanks to the above site/blog for the 411

A Blast from the past

Similar to previously expressed theories, the development of a cure for a disease must start with a theory of what are the particulates of that disease's etiology. Then things can be taken apart and then "fixed". We need not have to wait to fix the end = disease.

The alternative exists in the thing broken being unaltered in the first place by the avoidance of the thing that broke it. Oil and its by-products are by and far the biggest things to avoid. Yet this is not the total answer to the genetic disease problem in Huntington's Chorea (HC) and Parkinsonism (P) .

Let us look at an "old " article from NEUROPEPTIDES from 1991 (volume18 page 69-73, as an illustration. In this article a thing (SP= substance P) involved intimately with inflammation had been found elevated in the fluid surrounding the brain (CSF= cerebro-spinal fluid), in patients with the aforementioned diseases. If that substance , or the product of its action could be arrested the disease could be avoided in the population at risk.

This could be done in utero also avoiding the need of stem cell
researched products and allowing for natural gene expression and normalacy of life and its functions. This is what I mean by believing one needs a change of clothing. Why buy clothes when God gives them to you. They just need to be cleaned and kept unsoiled - comprende???

Oil for profit, but at what cost?

See BBC for picture and original(Hit link below for more details)

Nigeria seeks to end 'blood oil'

Stealing crude oil requires government cover, activists say
An international cartel of oil smugglers steals billions of dollars in "blood oil" from Nigeria, trading it for guns, the president has said.
Speaking at the G8 summit in Japan, President Umaru Yar'Adua drew comparisons between oil "bunkering" and the trade in "blood diamonds".
He said an international effort must be made to stop the trade, which fuelled unrest in the Niger Delta.
The conflict means Nigeria is no longer Africa's largest oil exporter.
Militant attacks in the Delta have reduced production by around a quarter, allowing Angola to overtake Nigeria.
But no-one really knows exactly how much oil is pumped out of the ground, according to a Senate inquiry set up in March.
The smuggling cartel includes officials at the Nigerian state oil company, government, the military and international oil companies, according to Delta activists.
Cheap oil
Trying to stop the trade must be an international effort, the president says, because the people driving the market are companies looking for cheap crude to feed international markets.

Elusive peace in Nigeria's oil Delta
"Stolen crude should be treated like stolen diamonds because they both generate blood money," President Yar'Adua said.
"Like what is now known as 'blood diamonds', stolen crude also aids corruption, violence and can provoke war."
The trade in diamonds helped fuel the conflicts in Sierra Leone and Angola, prompting campaigners to put pressure on the industry to tighten regulations.
A Rivers State government spokesman told the BBC it was time to crack down on the international members of the cartel.
"Some smart alec comes to Nigeria with a vessel partly loaded with guns, partly with cash," said Ogbonna Nwuke.
"In return, he gets cheap oil and delivers the weapons to some boys who think they're fighting the Niger Delta cause."
"The result is confusion."
Tankers
But activists in the Delta say there is no way oil smuggling could be done without the compliance of corrupt elements of the Nigerian state.
"I have never seen this bunkering business as an illegal thing," says Anyakwee Nsirimovu, a Port Harcourt-based human rights lawyer.
"For God's sake, the waters around Nigeria are not a free area, where you can just pass without anyone asking any questions."
In order for tankers to dock and receive oil from boats coming from the creeks, there must be a high level of involvement from government and the military, he says.
"They are making billions of dollars and they don't want this thing to end."

Gluttony can lead to death. Please do not say " I ate enough to kill me" Is this Biblical?

Thought for provoking

Just a thought for provoking

Jazz is not of this world. Well yes it was originally as it was being developed in its immature infancy and while under its initial oppression of the state and in the whorehouse. But now as an art form, the test in these last days is whether Jezebel likes it or not. If she does not like it , it is not of the world. He/She can not work her magic on the Johns or Johnettes who are thinking with the right brain and listening to jazz. If Jezebel does not like it, there is a sort of lack of a second (as in Robert's Rules of Order). There I go getting political again talking about religious people. This is why there is no desire for Blue Grass either (jazz also) with all that good pickin' goin' on.Neither the watchdog nor the watchman as musician in the pew can afford to play the animal that sticks its head in the sand to prevent the enemy from advancing. The enemy is in us. Our lusts, and desires and pride. The world and self is anti family and anti-creation period. Not only ant-jazz which is creative.There should be a clarion call to arms against self with prayer. There should be prayer for anyone who is suspected of showing a noose having read the Turner Dairies. Yet we need to read the Turner Diaries, and know that these are the last days. This is just one of the many misinterpretations of a person who does not love himself. Ther reason why I know is that I have had a first cousin to these insecurities. We need to pray for self and the sick-Ohs, and thank God that accept by grace go I.Another problem is that it (jazz) does not have a place to lay its head, rest, recuperate, rehearse, reiterate, run or relax outside of clubs that sell liquor. The consequence of this fact is grave and foreboding if you do not have faith. It is not like we can go to Jones Hall once a week and play it or listen to it. It is only because of racism and self-hatred that we are not allowed a legitimate home... in America! Yet the daily reprieve of a few places like Walker's Fine Foods, has does and will allow for the proliferation of the idiom.Thank God for those Walker brothers and for any parent that teaches their progeny the true history with LPs , pictures, movies or whatever to prevent self-hatred. If not a part of us as Americans dies.

En Espanol

Wednesday, May 28, 2008

La función disminuida del riñón en estrogens
Libremente pues he recibido libremente de dios como regalo debido a su donante el suyo engendrado solamente. Con todo necesité ser beggotten fuera de oscuridad mismo. Tuve que ser entregado del alcohol del otro 'spirits" eso viene en ciertas botellas y latas y las mercancías secadas. Ahora tengo un apego a los tallarines romanos. Tengo gusto del pecante del camarón. ¡Estaba trastornado cuando subieron en el almacén de 99 centavos a partir del 25 a 29 centavos! ¿Es esto sano? ¡No! Sin embargo necesito darte algo caliente de la prensa. Los estrógenos orales en mujeres posmenopáusicas están causando falta renal. Consultar por favor el byKidney hasta ahora publicado que la terapia oral internacional del estrógeno en mujeres posmenopáusicas se asocia a la pérdida del functionSofia B Ahmed1,2 del riñón, Bruce F Culleton1,2, Marcelo Tonelli2,3, Scott W Klarenbach2,3, Jennifer M MacRae1,2, Jianguo Zhang1,2 del artículo y protegen a las mujeres de Brenda R Hemmelgarn1,2 generalmente contra la pérdida progresiva de función del riñón; sin embargo, esta ventaja parece disminuir con menopausia. Debido a informes contradictorios en la asociación entre el uso de la terapia de la hormona y la función del riñón estudiamos a 5845 mujeres (1459 en terapia de la hormona y 4386 no utilizadores) que estaban durante 66 años de edad y tenían por lo menos 2 medidas de la creatinina del suero durante el período del estudio de 2 años. Después del ajuste para los covariates, el uso de la hormona (estrógeno-solamente, progestina-solamente, o ambas) fue asociado a una pérdida significativa de GFR estimado mientras que el resultado primario junto con un riesgo creciente de pérdida rápida de función del riñón como el resultado secundario comparó a los no utilizadores. Este índice creciente de pérdida fue asociado a uso oral pero no transvaginal del estrógeno. Una dosis acumulativa creciente del estrógeno también fue asociada a una mayor declinación en GFR estimado. ¡Nuestro estudio demuestra una asociación independiente en una manera dose-dependent del uso del estrógeno y la pérdida de función del riñón en esta INFORMACIÓN MÉDICA Y EDUCACIÓN mayores (AMIE) 1.Initiator 2.Prod/3.Prod creciente actividad/4.Jnl disminuido actividad/cambio del uso 2.no del estrógeno de population.ADVANCED del vol./de la página 5.Author/de Yr6.Misc/del vol./de Ed 1.Oral o los cambios de insignificant/GFR/la función transvaginal 4.kidney International/08 5.Sofia B Ahmed/Bruce F Culleton/Marcelo Tonelli/Scott W Klarenbach/Jennifer M MacRae/Jianguo Zhang/Brenda R Hemmelgarn/20086.sofia.ahmed@calgaryhealthregionWrite del estrógeno 3.gfr/renal ella y te dice que la oiste de nosotros! ¡Pedir que ella hable en tu reunión profesional médica!
Posted by Alonzo Peters MD at 12:03 PM 0 comments

Deutsch

Gedacht für das ErregenGerade ein Gedanke für das ErregenJazz ist nicht von dieser Welt. Brunnen ja war er ursprünglich, während er in seiner unreifen Kindheit entwickelt wurde und während unter seiner Anfangsunterdrückung des Zustandes und im Whorehouse. Aber jetzt als Kunstform, ist der Test an diesen letzten Tagen, ob Jezebel es oder nicht mag. Wenn sie es nicht mag, ist es nicht von der Welt. He/She kann ihre Magie auf dem Johns oder dem Johnettes nicht bearbeiten, die mit dem rechten Gehirn denken und zum Jazz hören. Wenn Jezebel es nicht mag, gibt es eine Art des Fehlens von einer Sekunde (wie Roberts in den Richtlinien des Auftrages). Dort gehe ich, politische wieder sprechende fromme Leute zu erhalten. Deshalb gibt es keinen Wunsch nach blauem Gras auch nicht (Jazz auch) mit allem, dem gutes pickin goin auf. Weder können der Wachhund noch der Wächter als Musiker in der Bank sich leisten, das Tier zu spielen, das seinen Kopf im Sand haftet, um den Feind am Voranbringen zu verhindern. Der Feind ist in uns. Unsere Sinneslüste und Wünsche und Stolz. Die Welt und der Selbst ist Antifamilie und Anti-kreation Zeitraum. Nicht nur Ameisejazz, der kreativ ist. Es sollte einen Fanfareanruf zu den Armen gegen Selbst mit Gebet geben. Es sollte Gebet für jedermann geben, das vom Zeigen einer Schleife vermutet wird, welche die Turner Molkereien gelesen wird. Dennoch müssen wir die Turner Tagebücher lesen und wissen, dass diese die letzten Tage sind. Dieses ist gerade eins der vielen Fehlinterpretationen einer Person, die sich nicht liebt. Folgern, warum ich bin weiß, dass ich einen ersten Vetter zu dieser Unsicherheit gehabt habe. Wir müssen für Selbst- und die kranken-Ohs beten und danken Gott, die durch Anmut gehen I.Another Problem ist annehmen, dass es (Jazz) nicht einen zu proben hat, zu reiterieren, zu laufen oder sich zu entspannen Platz, zum seines Kopfes zu legen, außerhalb der Vereine stillzustehen, zu genesen, dass Verkauf Alkohol. Die Konsequenz dieser Tatsache ist ernst und Vorahnung, wenn du nicht Glauben hast. Sie ist, nicht wie wir zu Jones Hall einmal wöchentlich gehen und sie spielen oder zu ihr hören können. Sie ist nur wegen des Rassismus und des Eigenhasses, dass uns nicht ein gesetzmaßiges Haus… in Amerika erlaubt werden! Dennoch mögen die tägliche Begnadigung einiger Plätze feine Nahrungsmittel des Wanderers, haben tut und wird zulassen die starke Verbreitung des Idioms. Gott für jene Wandererbrüder und für jedes mögliches Elternteil danken, das ihren Nachkommen die zutreffende Geschichte mit Langspielplatten, Abbildungen, Filme beibringt, oder was auch immer, zum des Eigenhasses zu verhindern. Wenn nicht ein Teil von uns als Amerikanern stirbt.

English

Clin J Am Soc Nephrol 3: 691-698, 2008Endothelial Dysfunction in Patients with Chronic Kidney Disease Results from Advanced Glycation End Products (AGE)-Mediated Inhibition of Endothelial Nitric Oxide Synthase through RAGE ActivationEllena Linden*, Weijing Cai , John C. He*, Chen Xue , Zhu Li , Jonathan Winston*, Helen Vlassara , and Jaime Uribarri* * Division of Nephrology, Department of Medicine, and Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York Correspondence: Dr. Jaime Uribarri, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029. Phone: 212-241-1887; Fax: 212-369-9339; E-mail: jaime.uribarri@mssm.edu Background and objectives: Advanced glycation end products, known pro-inflammatory and pro-oxidative compounds that accumulate in patients with chronic kidney disease, may play a major role in their high prevalence of endothelial dysfunction and subsequent cardiovascular disease. This study examined the association of advanced glycation end product accumulation with cellular receptor for advanced glycation end product expression and endothelial dysfunction as well as the mechanisms of this association in chronic kidney disease. Design, setting, participants, & measurements: A cross-sectional study was conducted of ambulatory patients without diabetes and with different stages of chronic kidney disease (n = 51), compared with gender- and age-matched healthy subjects. Fasting blood was obtained for measurement of advanced glycation end products and mRNA receptor for advanced glycation end product expression in peripheral blood mononuclear cells. Endothelial reactivity was assessed by the microcirculatory response to local ischemia (postocclusive reactive hyperemia) and local hyperthermia (thermal hyperemia). Sera were pooled and passed through affinity columns to separate advanced glycation end product–rich fractions, which were incubated with human aortic endothelial cells, with or without blockade of receptor for advanced glycation end product, to measure their effect on endothelial nitric oxide synthase. Results: Glomerular filtration rate correlated with serum advanced glycation end product, mRNA receptor for advanced glycation end product levels, postocclusive reactive hyperemia, and thermal hyperemia. Serum advanced glycation end product correlated with receptor for advanced glycation end product and inversely with postocclusive reactive hyperemia. Advanced glycation end product–rich fractions from chronic kidney disease sera suppressed endothelial nitric oxide synthase expression of human aortic endothelial cells compared with sera from healthy subjects, an effect abrogated by receptor for advanced glycation end product blockade. Conclusions: This study demonstrates for the first time an association of excess advanced glycation end product burden with increased peripheral blood mononuclear cell mRNA receptor for advanced glycation end product and in vivo endothelial dysfunction in patients with chronic kidney disease. Endothelial dysfunction in chronic kidney disease may be partly mediated by advanced glycation end product–induced inhibition of endothelial nitric oxide synthase through receptor for advanced glycation end product activationInitiator Prod / Activ Prod / Activ Jnl / Vol / Pg Author / Yr Misc / Vol / Edtnf cachexia lipoprotein lipase j. exp. med./154/631 kawkami/cerami/'81 trypanosome brucei infections tnf cachexia lipoprotein lipase j. exp. med./154/631 kawkami/cerami/'81 trypanosome brucei infections D-dimer measurement abnormality diagnosis of clotting/coagulation type diseases such as DVT< PE RHD< RF related heart disease death AMIE/entry #/1 peters. a/05 last check 7262 Note cancer also may involve clotting abnormalities either as a result of or consequence of CA state. Maeasurement of an abnormality may be preventative with respect to advanced diagnosisNO SNAP IL12 by feedback inhibition Eur Jnl Imm/28/12 huang,fp/98 NOS inhibitors include LNMMA / also diminish TNF a/ peritoneal macrophages stim by IFN /LPS enhance IL12 synthesisheart attack/MI clotting via /circumflex/LMDA/RCA/putrification/tnf action/apoptosis cells blood flow to heart/cardiac muscle function/bf brain/life of body/NC life of soul/ amie/1/1/ a peters/90 vitamine c/glutathione reserves /determine prognosisMutatations/claudin-19/ transmembrane/tight junction proteins/nephrocalcinosis/hypercalciuria/familial hypomagnesemia/ RF/Mg+2s/ Am J Physiol Renal Physiol/ 293/ F166-F177/renal physiology angelow,s/ Randa El-Husseini/ Sanae A. Kanzawa/ Alan S. L. Yu/ 07 Angelow, S., et al. - Claudins form/ family of transmembrane /tight junction proteins / control /selectivity / paracellular transport/ Mutations/ claudin-19/ expressed /kidney/ retina/ myelinated peripheral neurons/familial hypomagnesemia /hypercalciuria /nephrocalcinosisMM/renal cast hearing loss/bilat/hyperviscosity syndrome plasmaphersis International Urology and Nephrology/springer Mufazzal Ahmad/07 acute onset, probably due

Deutsch

Clin J morgens Soc Nephrol 3:691 - 698, 2008Endothelial Funktionsstörung bei Patienten mit chronischen Niere-Krankheit-Resultaten von vorgerückten Glycation Endprodukten (ALTER) - vermittelte Hemmung des Endothelial StickstoffoxidSynthase durch RASEREI AktivierungEllena Linden*, Weijing Cai, John C. He*, Chen Xue, Zhu Li, Jonathan Winston*, Helen Vlassara und Jaime Uribarri* * Abteilung der Nephrologie, Abteilung von Medizin und Abteilung des experimentellen Diabetes und des Alterns, Abteilung von Geriatrie, Berg Sinai-medizinische Fakultät, New York, New York Korrespondenz: Dr. Jaime Uribarri, Berg Sinai-medizinische Fakultät, ein Gustave Steuer-Platz, New York, NY 10029. Telefon: 212-241-1887; Telefax: 212-369-9339; EMail: jaime.uribarri@mssm.edu Hintergrund und Zielsetzungen: Vorgerückte glycation Endprodukte, bekannte Pro-entzündliche und Pro-oxydierende Mittel, die bei Patienten mit chronischer Nierekrankheit ansammeln, können die wichtige Rolle in ihrem hohen Vorherrschen der endothelial Funktionsstörung und der folgenden kardiovaskulären Krankheit spielen. Diese Studie überprüfte die Verbindung der vorgerückten glycation Endproduktansammlung mit dem zellularen Empfänger für vorgerückten glycation Endproduktausdruck und endothelial Funktionsstörung sowie die Mechanismen dieser Verbindung in der chronischen Nierekrankheit. Entwurf, Einstellung, Teilnehmer, & Maße: Eine Querschnittsstudie wurde von den ambulatorischen Patienten ohne Diabetes und mit den verschiedenen Stadien der chronischen Nierekrankheit (n = 51) geleitet, verglichen mit den Geschlecht und altersmäßig angepassten gesunden Themen. Fastendes Blut wurde für Maß der vorgerückten glycation Endprodukte und des mRNA Empfängers für vorgerückten glycation Endproduktausdruck in den einkernigen Zellen des Zusatzbluts erreicht. Endothelial Reaktivität wurde durch die mikrozirkulatorische Antwort zur lokalen Ischämie (postocclusive reagierende Hyperämie) und zur lokalen Hyperthermie festgesetzt (thermische Hyperämie). Seren wurden durch Affinität Spalten vereinigt und geführt, um vorgerücktes glycation Ende Produkt-reiche Brüche, die mit menschlichen endothelial Aortenzellen ausgebrütet wurden, mit oder ohne Blockade des Empfängers für vorgerücktes glycation Endprodukt zu trennen, um ihren Effekt auf endothelial Stickstoffoxid Synthase zu messen. Resultate: Knäuelförmige Filtrationrate bezog mit Serum fortgeschrittenem glycation Endprodukt, dem mRNA Empfänger für vorgerückte glycation Endproduktniveaus, postocclusive reagierender Hyperämie und thermischer Hyperämie aufeinander. Serum brachte das glycation Endprodukt voran, das mit dem Empfänger für vorgerücktes glycation Endprodukt und umgekehrt mit postocclusive reagierender Hyperämie aufeinander bezogen wurde. Vorgerücktes glycation Ende Produkt-reiche Brüche von den chronischen Nierekrankheitseren unterdrückten endothelial Stickstoffoxid Synthaseausdruck der menschlichen endothelial Aortenzellen, die mit Seren von den gesunden Themen, einen Effekt verglichen wurden, der durch Empfänger für vorgerückte glycation Endproduktblockade geabschafft wurde. Zusammenfassungen: Diese Studie zeigt zum ersten Mal eine Verbindung der Überfluss fortgeschrittenen glycation Endproduktbelastung mit dem erhöhten einkernigen Empfänger mRNA Zelle des Zusatzbluts für vorgerücktes glycation Endprodukt und in vivo endothelial Funktionsstörung bei Patienten mit chronischer Nierekrankheit. Endothelial Funktionsstörung in der chronischen Nierekrankheit kann durch vorgerücktes glycation Ende Produkt-verursachte Hemmung des endothelial Stickstoffoxid Synthase durch Empfänger für vorgerückte glycation Endproduktaktivierung teils vermittelt werdenInitiator-Stoß/Activ Stoß/Activ Jnl/Vol./Seite Autor/Jahr Verschieden/Vol./Edtnf Cachexia-Lipoproteinlipase J. exp. MED. /154/631 kawkami/cerami/'81 trypanosome brucei Infektion tnf Cachexia-Lipoproteinlipase J. exp. MED. /154/631 kawkami/cerami/'81 trypanosome brucei Infektion D-Dimer Maß-Abweichung Diagnose der Gerinnen/Koagulationart Krankheiten wie DVT< PET RHD< Rf bezog Herzkrankheit-TodAMIE/entry #/1 peters. a/05 kann letzter Überprüfung 7262 Anmerkung Krebs gerinnende Abweichungen entweder resultierend aus oder Konsequenz des CA Zustandes auch mit einbeziehen. Maeasurement einer Abweichung kann in Bezug auf vorgerückte Diagnose vorbeugend seinKEIN VERSCHLUSS IL12 durch Rückgesprächhemmung Eur Jnl Imm/28/12 Huang, fp/98 Nr. Hemmnisse schließen mit ein, LNMMA/vermindern auch TNF, das ein peritoneales Makrophagen stim durch IFN /LPS Synthese IL12 erhöhendas Herz attack/MI, das über /circumflex/LMDA/RCA/putrification/tnf Tätigkeit/apoptosis Zellen Durchblutung zum Herz-/Herzmuskelfunction/bf Gehirn/zum Leben des body/NC Lebens der Seele amie/1/1/ein peters/90 Vitamin c/glutathione gerinnt, hebt /determine Prognose aufMutatations/claudin-19/Transmembrane/fest NierenPhysiol/293/F166-F177/renal angelow Physiologie der Verzweigung Proteine/nephrocalcinosis/hypercalciuria/familial hypomagnesemia/RF/Mg+2s/morgens J Physiol, s Randa El-Husseini/Sanae A. Kanzawa/Alan S.L. Yu/07 Angelow, S., et al. - Claudins Formfamilie der Transmembrane-/tight Verzweigung Proteine/Steuerung /selectivity/parazellulare Transport Veränderungen claudin-19/drückte /kidney/ Retinamyelinated Zusatzneuronen/Familienhypomagnesemia /hypercalciuria /nephrocalcinosis ausMM/renal warf plasmaphersis Syndrom des Verlusts der Hörfähigkeit/bilat/hyperviscosity internationale Urologie und Nephrologie/Springer Mufazzal Ahmad/07 den akuten Anfang, vermutlich passend

Italiano

3:691 di Clin J Soc Nephrol - 698, 2008Disfunzione Endothelial in pazienti con i risultati cronici di malattia di rene dai prodotti finiti avanzati di Glycation (ETÀ) - inibizione mediata di Synthase Endothelial dell'ossido nitrico con l'attivazione di COLLERAEllena Linden*, Weijing Cai, John C. He*, Chen Xue, Zhu Li, Jonathan Winston*, Helen Vlassara e Jaime Uribarri* * Divisione di nefrologia, reparto di medicina e divisione di diabete e di invecchiamento sperimentali, reparto di geriatria, Scuola di Medicina di monte Sinai, New York, New York Corrispondenza: Dott. Jaime Uribarri, Scuola di Medicina di monte Sinai, un posto di imposizione di Gustave, New York, NY 10029. Telefono: 212-241-1887; Fax: 212-369-9339; Email: jaime.uribarri@mssm.edu Priorità bassa ed obiettivi: I prodotti finiti avanzati di glycation, i residui pro-infiammatori e pro-ossidativi conosciuti che si accumulano in pazienti con la malattia di rene cronica, possono svolgere un ruolo importante nella loro alta prevalenza di disfunzione endothelial e della malattia cardiovascolare successiva. Questo studio ha esaminato l'associazione di accumulazione avanzata del prodotto finale di glycation con il ricevitore cellulare per l'espressione avanzata del prodotto finale di glycation e la disfunzione endothelial così come i meccanismi di questa associazione nella malattia di rene cronica. Disegno, regolazione, partecipanti, & misure: Uno studio rappresentativo è stato condotto dei pazienti ambulatori senza diabete e con differenti fasi della malattia di rene cronica (n = 51), rispetto agli individui sani di pari età e di genere. L'anima di digiuno è stata ottenuta per la misura dei prodotti finiti avanzati di glycation e del ricevitore del mRNA per l'espressione avanzata del prodotto finale di glycation in cellule mononucleari di anima periferica. La reattività Endothelial è stata valutata dalla risposta microcircolatoria ad ischemia locale (iperemia reattiva postocclusive) ed all'ipertemia locale (iperemia termica). I sieri sono stati riuniti e passato stati attraverso le colonne di affinità per separare le frazioni prodotto-ricche dell'estremità avanzata di glycation, che sono state incubate con le cellule endothelial aortiche umane, con o senza blocco del ricevitore per il prodotto finale avanzato di glycation, per misurare il loro effetto sullo synthase endothelial dell'ossido nitrico. Risultati: Il grado di filtrazione glomerulare correlato con il siero ha avanzato il prodotto finale di glycation, il ricevitore del mRNA per i livelli avanzati del prodotto finale di glycation, l'iperemia reattiva postocclusive e l'iperemia termica. Il siero ha avanzato il prodotto finale di glycation correlato con il ricevitore per il prodotto finale avanzato di glycation ed inversamente con iperemia reattiva postocclusive. Le frazioni prodotto-ricche dell'estremità avanzata di glycation dai sieri cronici di malattia di rene hanno soppresso l'espressione endothelial delle cellule endothelial aortiche umane rispetto ai sieri dagli individui sani, un effetto dello synthase dell'ossido nitrico abrogato dal ricevitore per il blocco avanzato del prodotto finale di glycation. Conclusioni: Questo studio dimostra per la prima volta un'associazione della difficoltà avanzata eccesso del prodotto finale di glycation con il ricevitore mononucleare aumentato del mRNA delle cellule di anima periferica per il prodotto finale avanzato di glycation e la disfunzione endothelial in vivo in pazienti con la malattia di rene cronica. La disfunzione Endothelial nella malattia di rene cronica può essere mediata parzialmente tramite inibizione prodotto-indotta estremità avanzata di glycation di synthase endothelial dell'ossido nitrico tramite il ricevitore per l'attivazione avanzata del prodotto finale di glycationPungolo dell'iniziatore/pungolo di Activ/Activ Jnl/volume/autore/anno della pagina vario/volume/Edlipasi J. exp della lipoproteina della cachessia del tnf. med. /154/631 di kawkami/cerami/'81 infezione trypanosome di brucei lipasi J. exp della lipoproteina della cachessia del tnf. med. /154/631 di kawkami/cerami/'81 infezione trypanosome di brucei diagnosi di anomalia di misura del D-dimero del tipo malattie coagulazione/di coagulazione quale DVT< PE RHD< La rf ha collegato i peters di morte AMIE/entry #/1 di malattia di cuore. a/05 l'ultimo cancro della nota del controllo 7262 anche può coinvolgere le anomalie di coagulazione come conseguenza di o la conseguenza della condizione di CA. Maeasurement di un'anomalia può essere preventivo riguardo alla diagnosi avanzataNESSUNO SCHIOCCO IL12 tramite inibizione di risposte l'EUR Jnl Imm/28/12 huang, inibitori di fp/98 no. include LNMMA/inoltre diminuisce TNF che uno stim peritoneale dei macrofagi da IFN /LPS aumenta la sintesi IL12il cuore attack/MI che si coagula via l'azione di /circumflex/LMDA/RCA/putrification/tnf/il flusso sanguigno cellule di apoptosis al cervello muscolo cardiaco/del cuore function/bf/alla durata di durata di body/NC di anima amie/1/1/peters/90 una vitamina c/glutathione riserva la prognosi di /determineTransmembrane di Mutatations/claudin-19//fortemente angelow renale di fisiologia delle proteine/nephrocalcinosis/hypercalciuria/familial hypomagnesemia/RF/Mg+2s/J Physiol Physiol/293/F166-F177/renal della giunzione, s Randa El-Husseini/Sanae A. Kanzawa/Alan S.L. Yu/07 Angelow, S., ed altri - la famiglia della forma di Claudins delle proteine/controllo /selectivity/mutazioni paracellulari claudin-19/della giunzione di /tight del transmembrane di trasporto ha espresso i neuroni periferici myelinated della retina di /kidney//hypomagnesemia familiare /hypercalciuria /nephrocalcinosisMM/renal ha lanciato l'urologia di plasmaphersis di sindrome di perdita della capacità uditiva/bilat/hyperviscosity e la nefrologia internazionale/l'inizio acuto Mufazzal Ahmad/07 di imposta della volta, probabilmente dovuto

Tuesday, April 7, 2009

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