From the Boston Globe
........a new understanding of everyday fatigue - the kind associated with a fundamental lack of energy, not the fatique caused by conditions such as anemia, or a lack of sleep - is emerging from labs around the country. Last month, leading physiologists gathered at the National Institute on Aging, part of the National Institutes of Health, and came up with a new paradigm of what happens in the brain and the rest of the body when a person has subjective feelings of fatigue.
The new understanding "is a fundamental jump forward in the study of fatigue," said Dr. Luigi Ferrucci, one of the conference organizers, and brings with it some good news for the tired among us.Scientists are now convinced that fatigue has a real, molecular basis, and that at least two major biological processes are involved: An excess of natural chemicals called pro-inflammatory cytokines, which the body pumps out in response to infection. And sluggish mitochondria, the tiny organelles